1 00:00:09,950 --> 00:00:07,100 we investigated how bacteria react to 2 00:00:12,200 --> 00:00:09,960 antibiotics in space why would you need 3 00:00:14,150 --> 00:00:12,210 to do that in space the reason is 4 00:00:15,830 --> 00:00:14,160 because a series of experiments in the 5 00:00:18,319 --> 00:00:15,840 past have shown several things but one 6 00:00:20,300 --> 00:00:18,329 of them is that if you have a culture of 7 00:00:22,790 --> 00:00:20,310 bacteria on earth and identical one in 8 00:00:24,019 --> 00:00:22,800 space after a few hours whenever you're 9 00:00:26,300 --> 00:00:24,029 done with the experiment you see that 10 00:00:29,089 --> 00:00:26,310 there are more cells in spaceflight than 11 00:00:30,439 --> 00:00:29,099 on earth and similarly another series of 12 00:00:33,139 --> 00:00:30,449 experiments have shown that their 13 00:00:35,479 --> 00:00:33,149 ability to form biofilms is improved in 14 00:00:37,340 --> 00:00:35,489 space and biofilms are associated with 15 00:00:39,380 --> 00:00:37,350 diseases another thing that has been 16 00:00:41,450 --> 00:00:39,390 observed in spaceflight is the their 17 00:00:44,139 --> 00:00:41,460 capability to cause disease in their 18 00:00:45,889 --> 00:00:44,149 host is also enhanced in space and 19 00:00:48,200 --> 00:00:45,899 finally the one that we're really 20 00:00:49,790 --> 00:00:48,210 focusing on on AES one is the fact that 21 00:00:51,380 --> 00:00:49,800 several experiments have seen that you 22 00:00:53,569 --> 00:00:51,390 need higher concentrations of 23 00:00:56,299 --> 00:00:53,579 antibiotics or you need more drugs to 24 00:00:58,849 --> 00:00:56,309 stop bacteria from growing in space so 25 00:01:00,290 --> 00:00:58,859 that is a bunch of bad things if you 26 00:01:01,729 --> 00:01:00,300 were thinking about human space 27 00:01:04,040 --> 00:01:01,739 exploration but actually it's an 28 00:01:07,130 --> 00:01:04,050 opportunity for us to investigate why 29 00:01:08,750 --> 00:01:07,140 and how bacteria are becoming so capable 30 00:01:10,070 --> 00:01:08,760 of surviving concentrations of 31 00:01:11,900 --> 00:01:10,080 antibiotics that on earth would kill 32 00:01:14,750 --> 00:01:11,910 them and that's a that's a good problem 33 00:01:16,130 --> 00:01:14,760 - a good opportunity to try to kill the 34 00:01:18,520 --> 00:01:16,140 bacteria that we currently can't kill 35 00:01:21,470 --> 00:01:18,530 with our drugs so you're talking about 36 00:01:23,390 --> 00:01:21,480 drug-resistant bacteria or what we call 37 00:01:26,570 --> 00:01:23,400 I guess superbugs exactly as Lourdes 38 00:01:28,610 --> 00:01:26,580 that's what we're talking about so right 39 00:01:30,020 --> 00:01:28,620 now in 2015 most people think if I have 40 00:01:31,910 --> 00:01:30,030 a bacterial infection and I go to the 41 00:01:33,920 --> 00:01:31,920 doctor get some antibiotics and it's all 42 00:01:35,660 --> 00:01:33,930 done but in reality there's a problem 43 00:01:37,520 --> 00:01:35,670 the drug resistance problem on earth 44 00:01:39,560 --> 00:01:37,530 that every year is worse as a matter of 45 00:01:40,910 --> 00:01:39,570 fact last year over a hundred thousand 46 00:01:42,740 --> 00:01:40,920 people died from that so just to put 47 00:01:44,720 --> 00:01:42,750 that in measurable human cost in 48 00:01:47,030 --> 00:01:44,730 perspective if this interview is 5 to 6 49 00:01:49,340 --> 00:01:47,040 minutes in length during that duration 50 00:01:50,810 --> 00:01:49,350 one person passed away which is really 51 00:01:52,850 --> 00:01:50,820 heartbreaking as scientists we need to 52 00:01:54,800 --> 00:01:52,860 do something and space-based research is 53 00:01:57,500 --> 00:01:54,810 allowing us to try a different way to 54 00:01:59,510 --> 00:01:57,510 tackle that problem to see how can we 55 00:02:01,490 --> 00:01:59,520 kill these bacteria so now you're 56 00:02:02,960 --> 00:02:01,500 analyzing the data are there any results 57 00:02:04,370 --> 00:02:02,970 you can share with us so far yeah 58 00:02:05,930 --> 00:02:04,380 there's some stuff that we can share for 59 00:02:08,089 --> 00:02:05,940 example we've seen something that had 60 00:02:09,889 --> 00:02:08,099 been reported before that that more 61 00:02:12,410 --> 00:02:09,899 cells grow in space compared to ground 62 00:02:13,290 --> 00:02:12,420 to earth but something that we also have 63 00:02:15,120 --> 00:02:13,300 observed is 64 00:02:17,370 --> 00:02:15,130 the fact that they're very much smaller 65 00:02:18,930 --> 00:02:17,380 in space the e.coli that we grew in the 66 00:02:21,840 --> 00:02:18,940 International Space Station was less 67 00:02:24,450 --> 00:02:21,850 than half in volume is it was 41% in 68 00:02:26,190 --> 00:02:24,460 volume a cell in space when you compare 69 00:02:27,810 --> 00:02:26,200 it to the exact same situation but grown 70 00:02:29,820 --> 00:02:27,820 on earth so that has several 71 00:02:31,830 --> 00:02:29,830 implications on on different processes 72 00:02:33,930 --> 00:02:31,840 but more interestingly than that is that 73 00:02:35,910 --> 00:02:33,940 we have identified specific genes that 74 00:02:37,080 --> 00:02:35,920 are responsible for other series of 75 00:02:39,270 --> 00:02:37,090 processes like the ones we were 76 00:02:41,520 --> 00:02:39,280 mentioning that we are interested in in 77 00:02:43,470 --> 00:02:41,530 continue investigating on AES too and 78 00:02:47,340 --> 00:02:43,480 but also some that are we're ready to 79 00:02:48,960 --> 00:02:47,350 publish so when will we see a es2 we're